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The tricyclic antidepressants and bupropion (Wellbutrin) are not FDA-approved for treatment of ADHD but are often used off-label. The tricyclic antidepressants affect levels of norepinephrine while bupropion affects levels of both norepinephrine and dopamine. Imipramine and desipramine are the most commonly used tricyclic antidepressants. However nortriptyline is also effective.
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